The role of DNA repair on cell killing by charged particles.

It can be noted that it is not simple double strand breaks (dsb) but the non-reparable breaks that are associated with high biological effectiveness in the cell killing effect for high LET radiation. Here, we have examined the effectiveness of fast neutrons and low (initial energy = 12 MeV/u) or high (135 MeV/u) energy charged particles on cell death in 19 mammalian cell lines including radiosensitive mutants. Some of the radiosensitive lines were deficient in DNA dsb repair such as LX830, M10, V3, and L5178Y-S cells and showed lower values of relative biological effectiveness (RBE) for fast neutrons if compared with their parent cell lines. The other lines of human ataxia-telangiectasia fibroblasts, irs 1, irs 2, irs 3 and irs1SF cells, which were also radiosensitive but known as proficient in dsb repair, showed moderated RBEs. Dsb repair deficient mutants showed low RBE values for heavy ions. These experimental findings suggest that the DNA repair system does not play a major role against the attack of high linear energy transfer (LET) radiations. Therefore, we hypothesize that a main cause of cell death induced by high LET radiations is due to non-reparable dsb, which are produced at a higher rate compared to low LET radiations.     

Transition of Planar Rotational Motion of an Asymmetric Spacecraft into Oscillatory Motion at Its Reentry into the Atmosphere

The motion of a spacecraft with small asymmetry relative to its center of mass is considered. The restoring aerodynamic moment of the spacecraft is described by the Fourier series in terms of the angle of attack with the two first sinusoidal and the first cosinusoidal terms. A solution for the angle of attack in the undisturbed rotational motion is found. The analytical expression is obtained for the integral of action taken along the separatrices that separate the rotational and oscillatory regions of the phase portrait of a system. The transition of the spacecraft's motion from planar rotational to oscillatory is investigated. This transition is caused by a slow variation of moment characteristic coefficients, as well as by the presence of small asymmetry and damping and slow variation of their coefficients. Analytical formulas are obtained for determining the times of transition from rotational to oscillatory motion, as well as for the critical angular velocity of beyond-the-atmosphere rotation. When this critical velocity is exceeded, body rotation proceeds for a long time interval (planar autorotation arises).     

Austrian dose measurements onboard space station MIR and the International Space Station--overview and comparison.

The Atominstitute of the Austrian Universities has conducted various space research missions in the last 12 years in cooperation with the Institute for Biomedical Problems in Moscow. They dealt with the exact determination of the radiation hazards for cosmonauts and the development of precise measurement devices. Special emphasis will be laid on the last experiment on space station MIR the goal of which was the determination of the depth distribution of absorbed dose and dose equivalent in a water filled Phantom. The first results from dose measurements onboard the International Space Station (ISS) will also be discussed. The spherical Phantom with a diameter of 35 cm was developed at the Institute for Biomedical Problems and had 4 channels where dosimeters can be exposed in different depths. The exposure period covered the timeframe from May 1997 to February 1999. Thermoluminescent dosimeters (TLDs) were exposed inside the Phantom, either parallel or perpendicular to the hull of the spacecraft. For the evaluation of the linear energy transfer (LET), the high temperature ratio (HTR) method was applied. Based on this method a mean quality factor and, subsequently, the dose equivalent is calculated according to the Q(LET infinity) relationship proposed in ICRP 26. An increased contribution of neutrons could be detected inside the Phantom. However the total dose equivalent did not increase over the depth of the Phantom. As the first Austrian measurements on the ISS dosimeter packages were exposed for 248 days, starting in February 2001 at six different locations onboard the ISS. The Austrian dosimeter sets for this first exposure on the ISS contained five different kinds of passive thermoluminescent dosimeters. First results showed a position dependent absorbed dose rate at the ISS.     

Sequence comparison techniques for multisensor data fusion andtarget recognition

A new class of techniques for multisensor fusion and target recognition is proposed using sequence comparison by dynamic programming and multiple model estimation. The objective is to fuse information on the kinematic state and “nonkinematic” signature of unclassified targets, assessing the joint likelihood of all observed events for recognition. Relationships are shown to previous efforts in pattern recognition and state estimation. This research applies “classical” speech processing-related and other sequence comparison methods to moving target recognition, extends the efforts of previous researchers through improved fusion with kinematic information, relates the proposed techniques to Bayesian theory, and applies parameter identification methods to target recognition for improved understanding of the subject in general. The proposed techniques are evaluated and compared with existing approaches using the method of generalized ambiguity functions, which lends to a form of Cramer-Rao lower bound for target recognition     

A wavelet multiresolution analysis for spatio-temporal signals

The wavelet filters of the conventional 3D multiresolution analysis possess homogeneous spatial and temporal frequency characteristics which limits one's ability to match filter frequency characteristics to signal frequency behavior. Also, the conventional 3D multiresolution analysis employs an oct-tree decomposition structure which restricts the analysis of signal details to identical resolutions in space and time. This paper presents a 3D wavelet multiresolution analysis constructed from nonhomogeneous spatial and temporal filters, and an orthogonal sub-band coding scheme that decouples the spatial and temporal decomposition processes     

Simulation of fast ablation

A brief review of studies on simulation and control of a porous cooling process taking into account material transpiration is given. An approximated solution for an equation of the one-dimensional problem of fast ablation is also presented.     

Recent Breakthroughs in RF Photonics for Radar Systems

Radar systems require transmission of very high purity signals. Photonics is now mature enough to achieve analog transmission with very low noise, strong immunity, and wide-bandwidth even in harsh environments. We present our recent developments of optimized optical links dedicated to radar and multifunction systems     

Two Methods of Spectral Estimation for SARSAT Signals

Search and rescue satellite aided tracking (SARSAT) depends on the processing of emergency locator transmitter (ELT) signals which are received by a satellite in low polar orbit. Since the signal from a distressed vehicle is normally immersed in a background of other ELT signals (false alarms), interference, and noise, different methods of spectral estimation can provide advantages in estimating carrier frequency. A comparison between average spectrum and minimum spectrum for several real signals is provided here.     

Wireless interconnection to test instruments

Manufacturers are increasingly offering Ethernet connectivity on their test instruments. An additional benefit of this connection method is the ease of conversion to wireless connectivity. This paper describes the Ethernet interface used in the remote control of a RF power amplifier and describes the conversion to wireless connection.     

Microdosimetric measurements of heavy ion tracks.

The biological effectiveness of radiations depends on the spatial pattern of ionizations and excitations produced by the charged particle tracks involved. Ionizations produced by both the primary ion and by energetic delta rays may contribute to the production of biologically relevant damage and to the concentration of damage which may effect the probability of repair. Although average energy concentration (dose) can be calculated using homogeneous track models, the energy is actually concentrated in small volumes containing segments of the ion and delta ray tracks. These local concentrations are studied experimentally using low pressure proportional counters, and theoretically, using Monte Carlo methods. Small volumes near an ion track may be traversed by a delta ray. If they are, the energy deposited will be similar to that produced by a single electron track in a low-energy x-ray irradiation. The probability of a delta ray interaction occurring decreases with the square of the radial distance from the track. The average energy deposited is the product of this probability and the energy deposited in an interaction. Average energy deposited calculated from measured interaction probability is in good agreement with the results of homogeneous track models.